1, 3-Dipolar Cycloadditions. LXXVI. Cycloadditions of Diazomethane to Substituted Butadienes

Theoretical study of 1, 3-dipolar cycloadditions of nitrone and fulminic acid with substituted ethylenes

Triazol-substituted titanocenes by strain-driven 1,3-dipolar cycloadditions

An operationally simple, convenient, and mild strategy for the synthesis of triazole-substituted titanocenes via strain-driven 1,3-dipolar cycloadditions between azide-functionalized titanocenes and cyclooctyne has been developed. It features the first synthesis of titanocenes containing azide groups. These compounds constitute 'second-generation' functionalized titanocene building blocks for f...

Iridium–catalyzed 1,3–dipolar cycloadditions

1,3–Dipolar cycloaddition reactions (DCR) are atom–economic processes that permit the construction of heterocycles. Their enantioselective versions allow for the creation of up to four adjacent chiral centers in a concerted fashion. In particular, well–defined half–sandwich iridium (III) catalysts have been applied to the DCR between enals or methacrylonitrile with nitrones. Excellent yield and...

Enantioselective copper-catalyzed 1,3-dipolar cycloadditions.

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.

In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.